A while ago I read an article in the Australian Sky and Telescope magazine showing the differences in city lights from space using photographs from the International Space Station. This is a NASA Youtube video of the same, there are some amazing differences where cities cross political boundaries for instance.
Currently, NASA can't send astronauts up to (or get them back from) the ISS themselves, but they are working on a new capsule for doing this. The first flight of this was a few days ago. There is an 'astronauts eye' video of the re-entry as well, which is quite amazing too.